What Bone Disorders Cause Elevated Alkaline Phosphatase?

What does alkaline phosphatase do in bone?

Bone ALP is a major regulator of bone mineralization.

It hydrolyzes inorganic pyrophosphate which is a naturally occurring inhibitor of mineralization.

Bone ALP also provides inorganic phosphate (from pyrophosphate and organic phosphomonoesters) for the synthesis of hydroxyapatite [7,8]..

How can I lower my alkaline phosphatase levels?

Make changes to your dietavoid fruits and vegetables served with high-calorie sauces or added sugar and salt.eat fish at least twice a week, ideally those high in omega-3 fatty acids, such as salmon or trout.opt for fat-free or low-fat milk and dairy products.More items…•

Does alkaline phosphatase increase with age?

Use age-appropriate reference populations for ranges: In children, serum alkaline phosphatase activity is considerably elevated and correlates well with the rate of bone growth. Additionally, patients over the age of 60 have somewhat higher values (up to 1.5 times normal) than younger adults.

What diabetes medications cause high levels of alkaline phosphatase?

It is important to consider that a medication may be the cause of an isolated raised alkaline phosphatase – but also consider other possible causes as well….Other drugs:Allopurinol.Methimazole.Disulfiram.Phenylbutazone.

What is a normal ALT level?

The normal value for ALT in blood ranges from 29 to 33 units per liter (IU/L) for males and 19 to 25 IU/L for females, but this value can vary depending on the hospital. This range can be affected by certain factors, including gender and age. It’s important to discuss your specific results with your doctor.

How do high levels of alkaline phosphatase indicate a bone abnormality?

Instead, it can indicate a bone disorder, such as Paget’s Disease of Bone, a condition that causes your bones to become abnormally large, weak, and prone to fractures. Moderately high levels of alkaline phosphatase may indicate conditions such as Hodgkin lymphoma, heart failure, or a bacterial infection.

What does high bone alkaline phosphatase mean?

Causes of high bone ALP include bone growth, healing fracture, acromegaly, osteogenic sarcoma, or bone metastases, leukemia, myelofibrosis, and rarely myeloma; so ALP is used as a tumor marker. Hyperthyroidism, by its effects upon bone, may also elevate ALP.

Can vitamin D deficiency cause elevated alkaline phosphatase?

Thus, vitamin D deficiency is usually accompanied by normal blood levels for calcium and phosphorus, high-normal or elevated levels of PTH, normal to elevated levels of total alkaline phosphatase, a low 24-hour urine calcium excretion rate, and low levels of total 25(OH)D.

What is a normal alkaline phosphatase level?

The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (µkat/L). Normal values may vary slightly from laboratory to laboratory. They also can vary with age and sex. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.

What does it mean when your Alt is high?

High levels of ALT may indicate liver damage from hepatitis, infection, cirrhosis, liver cancer, or other liver diseases. Other factors, including medicines, can affect your results. Be sure to tell your health care provider about all the prescription and over-the counter medicines you are taking.

Is alkaline phosphatase a tumor marker?

Alkaline phosphatase is used as a tumor marker. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased.

When should I worry about alkaline phosphatase?

Abnormal levels of ALP in your blood most often indicate a problem with your liver, gallbladder, or bones. However, they may also indicate malnutrition, kidney cancer tumors, intestinal issues, a pancreas problem, or a serious infection.

What is the treatment for high alkaline phosphatase?

A reduction in serum ALP was also seen in the euparathyroid subjects (2.4 +/- 0.77 to 2.2 +/- 0.64 mu kat/l, p = 0.03). This study indicates that treatment with active vitamin D is effective in reducing the increased bone turnover seen in subjects with both primary and secondary HPT.

Can arthritis cause high alkaline phosphatase?

Increased concentration of serum alkaline phosphatase (ALP) is a common feature in rheumatoid arthritis (RA), although its origin remains unclear.

What foods increase alkaline phosphatase?

The diet containing phosphorus, healthy fats, Zn, vitamin B12 and vitamin A can be started to increase alkaline phosphatase level.

Can statins increase alkaline phosphatase?

Atorvastatin hepatotoxicity can also present with a distinctly hepatocellular pattern of injury with marked elevations in serum aminotransferase levels and minimal or no increase in alkaline phosphatase.

Can osteoporosis cause elevated alkaline phosphatase?

Biver, et al. has also showed raised levels of bone alkaline phosphatase in osteoporotic patients compared to normal, and these high levels may be associated with prevalent vertebral fractures.

In which conditions does alkaline phosphatase increase?

Elevated levels of ALP in the blood are most commonly caused by liver disease, bile duct obstruction, gallbladder disease, or bone disorders. This test measures the level of ALP in the blood.

What is considered a very high level of alkaline phosphatase?

The ALP level in healthy adults should be 20–140 units per liter (U/L). Children tend to have significantly higher levels of ALP than adults because their bones are still growing. A person recovering from a bone injury may also have a raised ALP level in the 3 months after the injury while their bone heals.